Brief Communications Control of Motoneuron Survival by Angiogenin
نویسندگان
چکیده
Dairín Kieran,1* Jordi Sebastia,1* Matthew J. Greenway,2 Matthew A. King,1 Dervla Connaughton,1 Caoimhin G. Concannon,1 Beau Fenner,1 Orla Hardiman,3 and Jochen H. M. Prehn1 1Department of Physiology and Medical Physics and Royal College of Surgeons in Ireland (RCSI) Neuroscience Research Centre, RCSI, Dublin 2, Ireland, 2National Centre for Medical Genetics, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland, and 3Department of Neurology, Beaumont Hospital, Dublin 11, Ireland
منابع مشابه
Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease caused by the loss of motoneurons. The precise molecular and cellular basis for neuronal death is not yet well established, but the contemporary view is that it is a culmination of multiple aberrant biological processes. Among the proposed mechanisms of motoneuron degeneration, alterations in the homeostasis of RNA binding prote...
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Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder affecting motoneurons. Mutations in angiogenin, encoding a member of the pancreatic RNase A superfamily, segregate with ALS. We previously demonstrated that angiogenin administration shows promise as a neuroprotective therapeutic in studies using transgenic ALS mice and primary motoneuron cultures. Its mechanism of a...
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Background and Objective: To study the effect of deprenyl on neuroprotective or survival on motoneuron and on gliosis reaction. Materials and Methods: Sprague Dawley rats (250-300 gr) of Razi institution were used to determine the effect of deprenyl (2.50 mg/kg ) on neuroprotective or survival on motoneuron and on gliosis reaction through morphometry and immunohistochemistry methods. Resu...
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Angiogenin (ANG) promotes cell growth and survival. Under growth conditions, ANG undergoes nuclear translocation and accumulates in the nucleolus where it stimulates rRNA transcription. When cells are stressed, ANG mediates the production of tRNA-derived stress-induced small RNA (tiRNA), which reprograms protein translation into a survival mechanism. The ribonucleolytic activity of ANG is essen...
متن کاملStructural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons
Mutations in angiogenin (ANG), a member of the ribonuclease A superfamily, are associated with amyotrophic lateral sclerosis (ALS; sporadic and familial) and Parkinson's disease. We have previously shown that ANG is expressed in neurons during neuro-ectodermal differentiation, and that it has both neurotrophic and neuroprotective functions. Here we report the atomic resolution structure of nati...
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